Recently, Omicron BA.5 mutants have been detected in Xi’an and Beijing, and internationally, BA.4 and BA.5 are making waves everywhere, setting off a new round of epidemics, with 73, 83 countries and They are found in the region. For a long time, the new coronavirus variant seems to be getting weaker and weaker, and many people think it is just a large flu, so is BA.5 weaker? Possibly the opposite. According to industry experts, compared with the previous mutation, the new branch of BA.5 not only spreads faster and has a higher viral load, but also has a new situation of invading the lungs and having a strong immune escape ability, which must be closely watched. It is reported that the previous original strain of the new coronavirus can use proteins that are present in alveolar cells but not in the upper respiratory tract to invade human lungs, increasing the risk of severe illness. Omicron BA.1 loses this ability and most of the time only infects the upper respiratory tract , but BA.5 regained this ability and “regained” the lung infection. This is associated with the TMPRSS2 protein on the surface of human alveolar cells. Whether the virus can infect the lungs depends on whether or not it can make good use of this protein, and the earlier branches of Omicron cannot well interact with TMPRS .
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